Recombinant human neuregulin-1 beta 1 (NRG1-β1) is produced in E. coli in a tag-free format, yielding a biologically active protein suitable for research applications. NRG1-β1 is a member of the neuregulin family of growth and differentiation factors, which signal through ErbB receptor tyrosine kinases to regulate cell proliferation, differentiation, survival, and communication.

In humans, NRG1-β1 plays critical roles in nervous system development, synaptic plasticity, cardiac development, and muscle biology. It is particularly important for neuron-glia interactions and Schwann cell survival, and it has been implicated in cardiovascular repair and cancer biology. Recombinant NRG1-β1 is widely used in neuroscience, cardiology, cancer research, and regenerative medicine models.