R-Spondin1 (Human), Recombinant Protein, CHO, Tag Free
Premium CytoGrow™ growth factor suitable for stem cell research, tissue regeneration, developmental biology, and cancer studies.
CytoGrow™ Recombinant R-Spondin1 (Human), CHO, Tag Free
Recombinant human R-Spondin1 is expressed in CHO cells to ensure proper folding and authentic mammalian post-translational modifications. This tag-free protein retains the native structure and high bioactivity of human R-Spondin1, making it suitable for diverse applications in cell signaling and developmental biology research.
R-Spondin1 is a secreted protein that acts as a potent activator of the Wnt/β-catenin signaling pathway, playing a critical role in stem cell proliferation, tissue regeneration, and organ development. It enhances Wnt signaling by binding to LGR receptors and modulating receptor activity. Recombinant human R-Spondin1 is widely used in studies of stem cell biology, regenerative medicine, and cancer research.
| Synonym: | RSPO1; R-spondin1; RP11-566C13.1; CRISTIN3; FLJ40906; RSPO Rspo1; R-spondin; Rspondin; RP23-325M14.2; Roof |
| Species: | Human |
| Expression System: | Chinese hamster ovary cells (CHO) |
| Endotoxin: | ≤10 EU/mg |
| Appearance: | White powder, colorless clear liquid after reconstitution |
| Formulation | Lyophilized from a 0.2 μm filtered solution containing PBS, 5% mannitol, 0.1% Tween 80 |
| Reconstitution: | Recommended to redissolve in sterile deionized water |
| Shipping: | Ships overnight |
| Storage and Stability: | Store in a manual defrost freezer and avoid repeated freeze-thaw cycles. Lyophilized state: 36 months at -20°C to -80°C After reconstitution and under sterile conditions: 6 months at -20°C to -80°C 7-10 days at 2°C to 8°C |
Bioactivity
Data and References
Organoid Culture
Figure 1: CytoGrow™ growth factors enhance intestinal organoid growth
A. CytoGrow™ R-Spondin1 (Human) was used as a replacement for the growth factors in standard organoid culture medium. Results demonstrate robust intestinal organoid growth in Matrigel by day 6.
B. Representative morphology of intestinal organoids on day 6 cultured in standard organoid medium supplemented with growth factors from another brand.
C. Organoid growth area over 6 days shows that CytoGrow™ R-Spondin1 (Human) growth factor supports faster intestinal organoid expansion compared to other growth factors.
| Size | 1 μg, 10 µg, 50 μg, 1 mg, 10 mg, 100 mg, 1 g, 1 mL, 10 mL |
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