Category Archives: Research Highlight

Breakdown in Communication: Extracellular Vesicles Drive Lung Cancer Progression by Shuttling c-Myc

Cancer cell-derived and plasma-derived oncogenic extracellular vesicles uniquely carry the cell cycle activator c-Myc and promote cell cycle upregulation and cluster formation of healthy cells in a 3D microenvironment. Lung cancer is one of the most common and malignant types of cancer and has maintained a high mortality rate because the early stages of this […]

OSA 1777: A New Tool in the Fight Against Bone Cancer

Introducing OSA 1777, a cell line derived from recurring osteosarcoma, which unlike existing cell lines, forms spheroids in 3D culture reminiscent of osteosarcoma tumors. Osteosarcoma (OSA) is the most common type of childhood bone cancer. In children and young adults, OSA most often develops at the metaphysis of long bones, while craniofacial and axial osteosarcomas […]

A New Weapon Against an Old Foe: PPM1D Inhibitors Are a Promising New Treatment for a Deadly Childhood Brain Tumor

New mechanistic insights into the tumorigenesis of DIPG yield a novel potential treatment: PPM1D inhibitors Diffuse intrinsic pontine glioma (DIPG) is an aggressive childhood brainstem glioma that accounts for as much as 20% of all childhood brain tumors but has the highest mortality of any childhood brain cancer. The high mortality stems from the fact […]

B49 and the B(ea)ST: A novel BST-based analog, B49, may prevent breast cancer metastasis by disrupting BST-2 dimerization

Three-dimensional hydrogels help to unravel the role and mechanism of action of BST-2 in breast cancer growth and metastasis and introduce a putative new therapy Breast cancer is the second largest cause of cancer-related deaths in women, and it has been clinically sub-categorized into five distinct types: Luminal A, Luminal B, HER2-enriched, basal, and claudin-low. […]

Breaking the (cell) cycle: Introducing CDK9 as a prognostic biomarker and therapeutic target in synovial sarcomas

Repressing CDK9 blocks cell spheroid formation in 3D culture and delays growth of synovial sarcoma cells Synovial sarcoma is an aggressive malignant mesenchymal neoplasm that accounts for 5–10% of soft tissue sarcomas in childhood and adolescence. Over 90% of these types of sarcomas have been attributed to a balanced reciprocal translocation, t(X;18) (p11.2; q11.2). This […]

Getting to the root of the problem: Injectable VitroGel® 3D hydrogel scaffolds enhance odontogenic differentiation in vivo

The biocompatible and injectable VitroGel hydrogel culture system enhances pulp-dentin regeneration and has the potential for chair-side regenerative endodontic procedures Regenerative endodontic procedures are common for repairing immature permanent teeth with apical periodontitis. These procedures are commonly successful and result in stabilization of proper successful root development of previously contaminated teeth. However, for teeth exhibiting […]

Trk-ing down castration-resistant prostate cancer: 3D organoid models reveal a new drug target for an aggressive form of prostate cancer.

Three-dimensional cancer-derived organoids introduce TrkA as a promising new biomarker and target for a nearly incurable disease. Prostate cancer is one of the most prevalent types of cancer, and the leading cause of death in men living “Western” lifestyles. Prostate cancer is slow-growing and asymptomatic, and therefore, difficult to detect. Once detected, patients undergo multiple […]