Category Archives: Research Highlight

Targeting Soluble Vimentin to Suppress Metastatic Breast Cancer Models In Vivo and In Vitro

Institution: Precision Medicine Research Center, Seoul National University Team: Pang, K., Park, J., Ahn, S. G., Lee, J., Park, Y., Ooshima, A., Mizuno, S., Yamashita, S., Park, K.-S., Lee, S.-Y., Jeong, J., Ushijima, T., Yang, K.-M., & Kim, S.-J. Application: Targeting Vimentin to suppress metastasis breast cancer Disease Model: Breast Cancer Hydrogel: VitroGel® 3D Among […]

Comparison between 2D and 3D Cell Cultured Adipose-derived Mesenchymal Stem Cells

Institution: Cancer Center at the First Hospital of Jilin University Team: Qiliang Yin, Na Xu, Dongsheng Xu , Mingxin Dong, Xiumin Shi, Yan Wang, Zhuo Hao, Shuangshuang Zhu, Donghai Zhao, Haofan Jin, and Wensen Liu Application: In vitro models of adipose-derived mesenchymal stem cells Disease Model: Adipose-derived mesenchymal stem cells (ADMSCs) Hydrogel: VitroGel® RGD In recent […]

ATR and phospho-ATR ser428 (p-ATR) Expression in Ovarian Cancer Prognosis

ovarian cancer study

Institution: The First Affiliated Hospital of Zhengzhou University David Geffen School of Medicine at UCLA Team: Wenlong Feng, Dylan C. Dean, Francis J. Hornicek, Jinglu Wang, Yanyan Jia, Zhenfeng Duan, and Huirong Shi Application: Studying the relationship of ATR and p-ATR in 3D ovarian cancer models Disease Model: Ovarian Cancer Cell Lines Hydrogel: VitroGel® 3D […]

VitroGel Hydrogel Used to Bridge the Gap Between In Vivo and In Vitro Pancreatic Islet Beta-cells Studies

Institution: Xiamen Medical College Team: Tianshu Lan, Jingyi Guo, Xiaoming Bai, Zengjiong Huang, Zhimin Wei, Guicheng Du, GuoliangYan, Lebin Weng, Xue Yi Application: Development of 3D islet pancreatic beta-cells (β-cells) Disease Model: The mouse β islet cell line, β-TC-6 Hydrogels: VitroGel® RGD, VitroGel® 3D, VitroGel® Cell Recovery Solution Islet transplantation is currently the only firmly […]

Inhibition of Scar Proliferation with In-situ Cross Bonding of VitroGel Hydrogel and Adipose-derived Stem Cells Conditioned Medium

Institution: Fujian Medical University Team: Chaoyu Zhang, Ting Wang, Li Zhang, Penghong Chen, Shijie Tang, Aizhen Chen, Ming Li, Guohao Peng, Hangqi Gao, Haiyan Weng, Haoruo Zhang, Shirong Li, Jinghua Chen, Liangwan Chen, Xiaosong Chen Application: Developing ADSCC-CM and VitroGel hydrogel complex to study hypertrophic scar prophylaxis Disease Model: Adipose-derived stem cells Hydrogel: VitroGel® RGD […]

Development of Hypoxic-Responsive Lipid Polymer Nanoparticle for Eradication of Residual Glioma Cells

Institution: Institute of Nervous System Diseases, Xuzhou Medical University, Xuzhou Team: Haoyue Xu, Yuhan Han, Gang Zhao, Long Zhang, Zongren Zhao, Zhen Wang, Liang Zhao, Lei Hua, Konduru Naveena, Jun Lu, Rutong Yu, and Hongmei Liu Application: Testing Lipid Polymer nanoparticle (LN) on in vivo and in vitro glioblastoma models. Disease Model: Glioblastoma Hydrogel: VitroGel® […]

Cyclin-dependent kinase 7 (CDK7) Overexpression Implicated as an Independent Predictor of Poor Prognosis of Osteosarcoma

Institution: Department of Orthopedic Surgery at UCLA Team: Hangzhan Ma, Dylan C. Dean, Ran Wei, Francis J. Hornicek and Zhenfeng Duan Application: 3D culture to evaluate the effects of CDK7 in an in vivo environment Disease Model: Osteosarcoma Hydrogel: VitroGel® 3D Osteosarcoma is the most common primary tumor of bone and accounts for 35% of […]

3D Printed Tumor Spheroids for Disease Modeling and Chemotherapeutic Drug Screening

Institution: Florida A&M University Team: Aragaw Gebeyehu1,4, Sunil Kumar Surapaneni1,4, John Huang2, Arindam Mondal1, Vivian Ziwen Wang2, Nana Fatima Haruna2, Arvind Bagde1, Peggy Arthur1, Shallu Kutlehria1, Nil Patel1, Arun K. Rishi3 & Mandip Singh1* Application:  3D bioprint of cancer cell lines to perform drug testings. Cell types: NSCLC-PDX, MDA MB231 WT, and HCC B-27 cells […]

Targeting Gangliosides for Melanoma Brain Metastasis Treatment

In vitro three-dimensional analysis elucidates the role of cell surface GD3 ganglioside and ST8SIA1 in melanoma brain metastasis. Institution: John Wayne Cancer Institute (JWCI), Fudan University, Providence St. Joseph Health Center, Tel-Aviv University, The University of Texas MD Anderson Cancer Center, Oregon Health and Science University (OHSU) Knight Cancer Institute Portland Team: Romela Irene Ramos, […]

Penetrating Cancer Stem Cells For Lung Cancer Treatment

Scientists from Florida A&M University have discovered the ability of Tel and DXTPL combination system to increase the power of DXTPL to penetrate cancer stem cells and decrease the chances of cancer relapse and metastasis. Institution: Florida A&M University Team: Peggy Arthur, Nilkumar Patel, Sunil Kumar Surapaneni, Arindam Mondal, Aragaw Gebeyehu, Arvind Bagde, Shallu Kutlehria, […]