Category Archives: Research Highlight

B49 and the B(ea)ST: A novel BST-based analog, B49, may prevent breast cancer metastasis by disrupting BST-2 dimerization

Three-dimensional hydrogels help to unravel the role and mechanism of action of BST-2 in breast cancer growth and metastasis and introduce a putative new therapy Breast cancer is the second largest cause of cancer-related deaths in women, and it has been clinically sub-categorized into five distinct types: Luminal A, Luminal B, HER2-enriched, basal, and claudin-low. […]

Breaking the (cell) cycle: Introducing CDK9 as a prognostic biomarker and therapeutic target in synovial sarcomas

Repressing CDK9 blocks cell spheroid formation in 3D culture and delays growth of synovial sarcoma cells Synovial sarcoma is an aggressive malignant mesenchymal neoplasm that accounts for 5–10% of soft tissue sarcomas in childhood and adolescence. Over 90% of these types of sarcomas have been attributed to a balanced reciprocal translocation, t(X;18) (p11.2; q11.2). This […]

Getting to the root of the problem: Injectable VitroGel® 3D hydrogel scaffolds enhance odontogenic differentiation in vivo

The biocompatible and injectable VitroGel hydrogel culture system enhances pulp-dentin regeneration and has the potential for chair-side regenerative endodontic procedures Regenerative endodontic procedures are common for repairing immature permanent teeth with apical periodontitis. These procedures are commonly successful and result in stabilization of proper successful root development of previously contaminated teeth. However, for teeth exhibiting […]

Trk-ing down castration-resistant prostate cancer: 3D organoid models reveal a new drug target for an aggressive form of prostate cancer.

Three-dimensional cancer-derived organoids introduce TrkA as a promising new biomarker and target for a nearly incurable disease. Prostate cancer is one of the most prevalent types of cancer, and the leading cause of death in men living “Western” lifestyles. Prostate cancer is slow-growing and asymptomatic, and therefore, difficult to detect. Once detected, patients undergo multiple […]