Category Archives: Research Highlight

Silent Partner: The MYC-related pseudogene HMGA1P6 drives malignancy in ovarian cancer

In vitro three-dimensional culture helps to demonstrate that several pseudogenes, including HMGA1P6, are involved in metastasis of ovarian cancer, introducing another unconventional target for cancer therapeutics. Ovarian cancer has the highest mortality of all gynecologic cancers and is often diagnosed at an advanced stage as there exist no effective screening protocols for earlier diagnosis. Moreover, […]

The injectable VitroGel provides a viable in vivo scaffold for novel maternal-fetal adipose stem cell transplant studies

Maternally derived adipose stem cells have emerged as a possible solution to the common immunological rejection observed in fetal repair surgeries. The continuing advancement of genetic testing capabilities has allowed for the earlier diagnosis of congenital birth defects in the fetus, promoting the development of fetal reconstructive surgeries that can correct defects, including brain anomalies, […]

VitroGel’s ability to enhance the ECM-cell interaction enhances transplantable capacity of MSCs in rat models of intervertebral disc regeneration

VitroGel RGD enhances stem cell transplantation to treat intervertebral disc degeneration using rat models, laying new foundations in the movement toward cell-based tissue therapies. Lower back pain caused by intervertebral disc degeneration is becoming increasingly common due to the growing aging population. However, there exists no common therapy that can effectively repair or regenerate the […]

Defrosting Fertility: VitroGel offers a viable alternative to ovarian tissue cryopreservation

In vitro three-dimensional culture of murine ovarian follicles in the VitroGel demonstrates superior morphology and growth compared to other biomaterials and 2D culture. Cancer treatment can adversely affect fertility in a number of ways, from ovum destruction resulting from chemotherapeutic treatment or radiation therapy to adverse effects of hormone secretion or function in response to […]

One step closer: ADK-L as a potential therapeutic target for aggressive metastatic breast cancer

Manipulation of the adenosine metabolite ADK-L may offer a way to modulate cell invasion and proliferation of breast cancer cells, offering a possible therapeutic solution to aggressive breast cancers. According to the American Cancer Society, breast cancer is one of the most prolific cancers in women in the United States, the second most common cause […]

Breakdown in Communication: Extracellular Vesicles Drive Lung Cancer Progression by Shuttling c-Myc

Cancer cell-derived and plasma-derived oncogenic extracellular vesicles uniquely carry the cell cycle activator c-Myc and promote cell cycle upregulation and cluster formation of healthy cells in a 3D microenvironment. Lung cancer is one of the most common and malignant types of cancer and has maintained a high mortality rate because the early stages of this […]

OSA 1777: A New Tool in the Fight Against Bone Cancer

Introducing OSA 1777, a cell line derived from recurring osteosarcoma, which unlike existing cell lines, forms spheroids in 3D culture reminiscent of osteosarcoma tumors. Osteosarcoma (OSA) is the most common type of childhood bone cancer. In children and young adults, OSA most often develops at the metaphysis of long bones, while craniofacial and axial osteosarcomas […]

A New Weapon Against an Old Foe: PPM1D Inhibitors Are a Promising New Treatment for a Deadly Childhood Brain Tumor

New mechanistic insights into the tumorigenesis of DIPG yield a novel potential treatment: PPM1D inhibitors Diffuse intrinsic pontine glioma (DIPG) is an aggressive childhood brainstem glioma that accounts for as much as 20% of all childhood brain tumors but has the highest mortality of any childhood brain cancer. The high mortality stems from the fact […]

B49 and the B(ea)ST: A novel BST-based analog, B49, may prevent breast cancer metastasis by disrupting BST-2 dimerization

Three-dimensional hydrogels help to unravel the role and mechanism of action of BST-2 in breast cancer growth and metastasis and introduce a putative new therapy Breast cancer is the second largest cause of cancer-related deaths in women, and it has been clinically sub-categorized into five distinct types: Luminal A, Luminal B, HER2-enriched, basal, and claudin-low. […]

Breaking the (cell) cycle: Introducing CDK9 as a prognostic biomarker and therapeutic target in synovial sarcomas

Repressing CDK9 blocks cell spheroid formation in 3D culture and delays growth of synovial sarcoma cells Synovial sarcoma is an aggressive malignant mesenchymal neoplasm that accounts for 5–10% of soft tissue sarcomas in childhood and adolescence. Over 90% of these types of sarcomas have been attributed to a balanced reciprocal translocation, t(X;18) (p11.2; q11.2). This […]