Authors: Rick Cohen, Ph.D., Kalhara Menikdiwela, Ph.D., John Huang, Ph.D. Abstract: Human induced pluripotent stem cells (iPSCs) offer a powerful launch point to study the cellular mechanisms of the developing embryo and the formation of organ systems. Further, they provide an invaluable tool for developing patient-specific models for studying disease processes and drug discovery. However, […]
Using TheWell Bioscience’s complete xeno-free 3D cell culture platform, we offer customized services that help reduce setup time, lower development costs, and accelerate your research. We work with your goals and budget to establish an optimized workflow, so you can focus on generating reliable and reproducible results. In addition, our scientists can work with you […]
ABSTRACT Predicting drug efficacy in oncological microphysiological systems (MPS) requires high-resolution longitudinal tracking of cell death pathways within dense 3D architectures. Traditional confocal methods struggle with light attenuation and phototoxicity during multi-day imaging. We present an example of a semi-automated HTS workflow using a system that (1) maintains the in vivo cancer phenotype by growing […]
Background The luminal progenitor (LP) population in the normal breast is under the control of paracrine progesterone signalling and likely represents the cell of origin of estrogen receptor negative (ER-) BC. Exogenous progestins, as contraception or menopausal hormone replacement therapy (HRT), increase the risk of ER- and ER+ BC. We sought to examine the effect […]
Join us at Microphysiological Systems (MPS) World Summit 2026 from May 26-29, 2026, at the Walter E. Washington Convention Center Explore a more advanced and adaptable approach to cell culture with VitroGel® hydrogels, RocketCell™ media, CytoGrow™ growth factors, VitroPrime™ cultureware, and Cyto3D® analysis. Together, these integrated solutions enable reproducible and scalable workflows for organoids, xenografts, […]
We were thrilled to welcome researchers from around the world to Booth #1941, where conversations centered on advancing cancer research through scalable, consistent, and clinically relevant models. A key highlight was the strong interest in our end-to-end xeno-free 3D cell culture platform—featuring VitroGel® hydrogels, RocketCell™ media, CytoGrow™ growth factors, VitroPrime™ cultureware, and Cyto3D® analysis. Built […]
Join us at AACR 2026 Annual Meeting from April 19–22, 2026, at the San Diego Convention Center. Discover a smarter, more flexible approach to advanced cell culture with VitroGel® hydrogels, RocketCell™ media, CytoGrow™ growth factors, VitroPrime™ cultureware, and Cyto3D® analysis. Together, these solutions support reproducible, scalable workflows across organoids, xenografts, invasion assays, stem cell culture, […]
Presenter: Julia Schueler, Ph.D. – Charles River Laboratories Abstract: The 3R principles are embedded in regulatory frameworks and industry standards. However, drug development pipelines are highly standardized and validated over decades. Introducing new models and adapting existing ones requires extensive validation. The need to compare data before and after these adaptations can lead to inconsistencies […]
Abstract: Epithelial-to-mesenchymal transition (EMT) is a key biological process that facilitates cancer metastasis to distant organs. Most preclinical studies investigating EMT are conducted using traditional two-dimensional (2D) culture models, which fail to recapitulate the in vivo tumor microenvironment, limiting the translational relevance of their findings to clinical settings. Consequently, three-dimensional (3D) culture systems have emerged […]
Abstract: Colorectal cancer (CRC) is the fourth most commonly diagnosed cancer and the second leading cause of cancer death in the United States of America. Organoids, specifically CRC organoids have emerged as a powerful preclinical model as they closely recapitulate patient-specific tumor features, including tumor morphology, genetics, and treatment response. However, most organoid culture systems […]
