Noggin (Human), Recombinant Protein, CHO, Tag Free

Premium CytoGrow™ growth factor suitable for embryonic development research, stem cell differentiation, tissue engineering, and BMP-related signaling studies.

CytoGrow™ Recombinant Noggin (Human), CHO, Tag Free

Recombinant human Noggin is expressed in CHO cells to ensure proper folding and authentic mammalian post-translational modifications. This tag-free protein retains the native structure and high bioactivity of human Noggin, making it suitable for diverse applications in developmental biology and cell signaling research.

Noggin is a secreted glycoprotein that functions as an antagonist of bone morphogenetic proteins (BMPs). By binding to BMPs, Noggin inhibits their interaction with receptors, playing a critical role in regulating embryonic development, tissue differentiation, and organogenesis. Recombinant human Noggin is widely used in studies involving stem cell differentiation, BMP pathway modulation, and developmental biology.

Specifications 

Synonym: Noggin; NOG
Species:Human
Expression System:Chinese Hamster Ovary cell line (CHO)
Endotoxin:≤10 EU/mg
Appearance:White powder, colorless clear liquid after reconstitution
Formulation Lyophilized from a 0.22 μm filtered solution containing PBS, 5% mannitol and 0.01% Tween 80
Reconstitution: Recommended to redissolve in sterile deionized water
Shipping:Shipped with ice pack
Storage and Stability:Lyophilized state:
36 months at -20°C to -80°C

After reconstitution and under sterile conditions:
6 months at -20°C to -80°C
7-10 days at 2°C to 8°C

Store in a manual defrost freezer and avoid repeated freeze-thaw cycles.

Resources


Booklet – CytoGrow Growth Factors

Product Data Sheet

Material Safety Data Sheet (MSDS)

Frequently Asked Questions 

Bioactivity

CytoGrow Noggin (Human) Bioactivity

Data and References

Organoid Culture

Figure 1: CytoGrow™ growth factors enhance intestinal organoid growth
A. CytoGrow™ Noggin (Human) was used as a replacement for the growth factors in standard organoid culture medium. Results demonstrate robust intestinal organoid growth in Matrigel by day 6.
B. Representative morphology of intestinal organoids on day 6 cultured in standard organoid medium supplemented with growth factors from another brand.
C. Organoid growth area over 6 days shows that CytoGrow™ Noggin (Human) growth factor supports faster intestinal organoid expansion compared to other growth factors.

Size

1 μg, 10 µg, 50 μg, 1 mg, 10 mg, 100 mg, 1 g, 1 mL, 10 mL