CytoGrow™ Recombinant Noggin (Human), CHO, Tag Free

Recombinant human Noggin is expressed in CHO cells to ensure proper folding and authentic mammalian post-translational modifications. This tag-free protein retains the native structure and high bioactivity of human Noggin, making it suitable for diverse applications in developmental biology and cell signaling research.

Noggin is a secreted glycoprotein that functions as an antagonist of bone morphogenetic proteins (BMPs). By binding to BMPs, Noggin inhibits their interaction with receptors, playing a critical role in regulating embryonic development, tissue differentiation, and organogenesis. Recombinant human Noggin is widely used in studies involving stem cell differentiation, BMP pathway modulation, and developmental biology.

Data and References

Organoid Culture

Figure 1: CytoGrow™ growth factors enhance intestinal organoid growth
A. CytoGrow™ Noggin (Human) was used as a replacement for the growth factors in standard organoid culture medium. Results demonstrate robust intestinal organoid growth in Matrigel by day 6.
B. Representative morphology of intestinal organoids on day 6 cultured in standard organoid medium supplemented with growth factors from another brand.
C. Organoid growth area over 6 days shows that CytoGrow™ Noggin (Human) growth factor supports faster intestinal organoid expansion compared to other growth factors.