Abstract: Human induced pluripotent stem cells (iPSCs) offer a powerful starting point to study the molecular dynamics of the developing nervous system. Further, they provide an invaluable tool for developing patient-specific models to study the disease process. Therefore, optimizing their growth in a defined, native 3D state is of paramount importance to both guide and […]
Abstract: The development of in vitro systems for long-term neuronal differentiation and survival is crucial for understanding both physiological processes and various disease states. While traditional two-dimensional (2D) neuron models have been instrumental in neuroscience research, these systems fail to maintain neuron viability over extended periods, impeding prolonged neuronal maturation. One reason for this limitation is that 2D-based models misrepresent […]
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Discover the Future of 3D Cell Culture at SfN – Neuroscience 2025 We’re excited to announce our first-ever participation at Neuroscience 2025! Join us on November 15–19, 2025, at the San Diego Convention Center to explore how VitroGel®, our xeno-free, synthetic hydrogel system, is driving the shift toward animal-free, reproducible, and scalable 3D cell culture […]
Abstract: Tamoxifen, an anti-oestrogen, is the only licensed medication in the UK for breast cancer prevention in high-risk, pre-menopausal women. Data from the Biomarkers of Breast Cancer Prevention (BBCP) trial show that, while tamoxifen reduces overall proliferation after three months of treatment, a subset of women (5/13) show stable or increased proliferation. As proliferation is […]
Uncovering the power of fibroblast-derived migrasomes in wound healing with the help of VitroGel® 3D’s advanced 3D culture system Effective skin wound healing requires precise cell–cell communication and coordination across tissue types. However, the role of newly discovered migrasomes—vesicular organelles derived from fibroblasts—was not fully understood in the context of tissue repair. To study these […]
VitroGel® Cell Invasion Assay Kit empowers researchers to model cancer invasion under physiologically relevant 3D conditions. Melanoma, a deadly form of skin cancer, is notorious for its ability to switch between growing and spreading – a phenomenon known as phenotypic plasticity. For decades, scientists have suspected that cues from the tumor’s surroundings trigger this switch, […]
VitroGel® ORGANOID 3 turns tumor–immune interactions into clear insights without the variability of animal-based matrices. A major challenge in ovarian cancer is chemotherapy resistance, often driven by the tumor’s immune microenvironment. Traditional culture systems fail to mimic these complex cell–cell interactions. Using VitroGel® ORGANOID 3 (VHM04-3), researchers at the University of New Mexico established 3D […]
VitroGel® empowers dynamic 3D organoid growth, revealing taste biology and beyond. Studying taste receptor cell biology is challenging due to their complex structure, short lifespan, and limited survival in vitro. Traditional static cultures often fail to maintain mature cell types and functional activity. In this study, researchers used VitroGel® Hydrogel Matrix within the ClinoStar® dynamic […]
VitroGel® RGD enables critical invasion assays to reveal the role of SPTSSA in tumor progression Gastric cancer (GC) is a deadly global health threat, often diagnosed too late due to its aggressive spread and ability to evade the immune system. A major hurdle in treatment is understanding how cancer cells invade tissues and suppress immune […]
