Author Archives: Kyra Baricaua

Xeno-Free 2D and 3D Neuron Culture Made Easy with VitroGel® NEURON

VitroGel® NEURON is a xeno-free hydrogel designed to closely mimic the native extracellular matrix, supporting the growth, differentiation, and maturation of neuronal cells. With its user-friendly, ready-to-use formulation, scientists can seamlessly transition between 2D and 3D cultures without the need for animal-derived components — significantly improving experimental consistency and translational relevance.

Time to Cut the Cord: Why Animal-Based ECMs Have No Place in the Future of 3D Cell Models

In April 2025, the U.S. Food and Drug Administration (FDA) announced a groundbreaking initiative to phase out the animal testing requirement for monoclonal antibodies and other drugs. This marked a significant milestone in the advancement of preclinical research. Experts from regulatory agencies, academia, and industry worldwide convened to promote the adoption of New Approach Methodologies […]

VitroGel® Takes the Fight to Fibrosis – Naringin Halts EMT in Lung Cells

VitroGel® takes the fight to fibrosis—making cell invasion studies faster, clearer, and more reliable. Pulmonary fibrosis, especially when triggered by toxins such as paraquat, is a life-threatening condition driven by inflammation, epithelial-mesenchymal transition (EMT), and invasive cell behavior. To understand and halt this progression, researchers require a physiologically relevant in vitro system that can mimic […]

Evaluating Spheroid Invasion with VitroGel® Hydrogel Matrix in VitroPrime™ Ultra-Low Attachment, U-Bottom, 96-well Plate

Introduction Spheroid invasion assays offer a physiologically relevant three-dimensional (3D) in vitro model for studying cancer cell behavior, surpassing the limitations of traditional two-dimensional (2D) cultures [1]. Spheroids are compact cell aggregates that recapitulate critical in vivo features, including cell–cell and cell–matrix interactions, as well as nutrient and oxygen gradients providing a more accurate representation […]