ABSTRACT Predicting drug efficacy in oncological microphysiological systems (MPS) requires high-resolution longitudinal tracking of cell death pathways within dense 3D architectures. Traditional confocal methods struggle with light attenuation and phototoxicity during multi-day imaging. We present an example of a semi-automated HTS workflow using a system that (1) maintains the in vivo cancer phenotype by growing […]
Monmouth Junction, NJ — May 19, 2026 — TheWell Bioscience, a biotechnology pioneering advanced 3D cell culture technologies, today announced the launch of its RocketCell™ Organoid Xeno-Free Essential-Core Medium, a chemically defined, universal foundation medium designed to streamline organoid culture workflows while enhancing reproducibility, scalability, and cost efficiency. As organoid models continue to expand across […]
Batch-to-batch variability and difficult handling associated with animal-derived matrices like Matrigel remain persistent challenges in organoid research, affecting reproducibility, translatability, and scalability. At TheWell Bioscience, we’ve built a fully xeno-free, end-to-end ecosystem specifically designed to help researchers standardize and simplify organoid development without sacrificing performance. Key products for organoid culture
Background The luminal progenitor (LP) population in the normal breast is under the control of paracrine progesterone signalling and likely represents the cell of origin of estrogen receptor negative (ER-) BC. Exogenous progestins, as contraception or menopausal hormone replacement therapy (HRT), increase the risk of ER- and ER+ BC. We sought to examine the effect […]
Join us at Microphysiological Systems (MPS) World Summit 2026 from May 26-29, 2026, at the Walter E. Washington Convention Center Explore a more advanced and adaptable approach to cell culture with VitroGel® hydrogels, RocketCell™ media, CytoGrow™ growth factors, VitroPrime™ cultureware, and Cyto3D® analysis. Together, these integrated solutions enable reproducible and scalable workflows for organoids, xenografts, […]
We were thrilled to welcome researchers from around the world to Booth #1941, where conversations centered on advancing cancer research through scalable, consistent, and clinically relevant models. A key highlight was the strong interest in our end-to-end xeno-free 3D cell culture platform—featuring VitroGel® hydrogels, RocketCell™ media, CytoGrow™ growth factors, VitroPrime™ cultureware, and Cyto3D® analysis. Built […]
Learn how a xeno-free 3D platform enables controlled EMT Modeling and GBM tumoroid formation Glioblastoma multiforme (GBM), the most aggressive form of brain cancer, remains highly challenging to treat, in part due to the protective effects of the blood–brain barrier. However, progress in developing effective therapies is also hindered by inadequate model systems that fail […]
Join us at AACR 2026 Annual Meeting from April 19–22, 2026, at the San Diego Convention Center. Discover a smarter, more flexible approach to advanced cell culture with VitroGel® hydrogels, RocketCell™ media, CytoGrow™ growth factors, VitroPrime™ cultureware, and Cyto3D® analysis. Together, these solutions support reproducible, scalable workflows across organoids, xenografts, invasion assays, stem cell culture, […]
Presenter: Julia Schueler, Ph.D. – Charles River Laboratories Abstract: The 3R principles are embedded in regulatory frameworks and industry standards. However, drug development pipelines are highly standardized and validated over decades. Introducing new models and adapting existing ones requires extensive validation. The need to compare data before and after these adaptations can lead to inconsistencies […]
Abstract: Epithelial-to-mesenchymal transition (EMT) is a key biological process that facilitates cancer metastasis to distant organs. Most preclinical studies investigating EMT are conducted using traditional two-dimensional (2D) culture models, which fail to recapitulate the in vivo tumor microenvironment, limiting the translational relevance of their findings to clinical settings. Consequently, three-dimensional (3D) culture systems have emerged […]
