TheWell Bioscience Launches VitroPrime™ 3D Culture and Imaging Plate for Organoid and 3D Cell Culture Workflows

A new in-plate, zero-disruption design enables reproducible organoid culture, downstream processing, and high-resolution imaging in a single 3D cell culture plate

Monmouth Junction, NJ — February 9, 2026 — TheWell Bioscience today announced the launch of the VitroPrime™ 3D Culture and Imaging Plate, a next-generation 3D cell culture plate engineered to support organoid and advanced 3D cell culture workflows with minimal physical disturbance. The VitroPrime™ plate enables long-term culture, fixation, immunofluorescence staining, and high-resolution imaging to be performed entirely in-plate—eliminating sample transfer while preserving fragile hydrogel-based 3D structures.

Through a unique combination of sample-locking architecture, passive media exchange, and imaging-grade optics, the VitroPrime™ 3D Culture and Imaging Plate addresses persistent challenges in 3D cell culture, including hydrogel floating, sample rotation, and sample loss during routine handling. By minimizing manual manipulation and vessel-to-vessel transfers, the plate improves reproducibility, supports longitudinal studies, and enables consistent data generation across experiments.

Most current 3D cell culture systems, including organoid models, rely on culture vessels originally designed for 2D monolayer cultures rather than delicate, hydrogel-based 3D constructs. As a result, routine media exchange and downstream processing frequently disrupt 3D architecture and spatial organization. In addition, fixation, staining, and imaging often require transferring samples between vessels, increasing the risk of structural damage, sample loss, and experimental variability. These limitations make it difficult to achieve reliable long-term culture, high-resolution imaging, and laboratory automation within a single 3D cell culture plate.

The VitroPrime™ 3D Culture and Imaging Plate was engineered to overcome these challenges by enabling a true end-to-end 3D workflow—from sample seeding and long-term culture to downstream processing and imaging—within a single vessel, with zero sample transfer and minimal physical disturbance.

“For years, we’ve spoken with researchers around the world who struggle to find the right culture vessel for 3D organoid workflows—one that can prevent hydrogel floating, allow live-cell tracking, enable easy media exchange and sample fixation without sample loss, and support high-resolution imaging,” said John Huang, CEO of TheWell Bioscience. “It took several years of rational design and iterative development to translate these unmet needs into a practical, scalable solution.”

At the core of the VitroPrime™ 3D Culture and Imaging Plate is a dedicated lateral media-exchange channel that enables passive, disturbance-free diffusion of nutrients, stains, and fixatives while preserving the integrity of delicate 3D constructs. An integrated anti-floating and anti-rotation design ensures stable positioning during longitudinal monitoring, organoid development studies, live-cell imaging, and high-content analysis. The plate also features an ultra-clear, premium cover-glass bottom optimized for high-resolution and confocal imaging.

The VitroPrime™ 3D Culture and Imaging Plate integrates seamlessly with TheWell Bioscience’s end-to-end, xeno-free 3D cell culture platform, including VitroGel® hydrogels, RocketCell™ media, CytoGrow™ growth factors, and Cyto3D® downstream analysis reagents. Together, the platform delivers a defined, scalable, and automation-ready workflow for more relevant and reproducible advanced 3D cell culture models.

For more information or to order, visit TheWell Bioscience website at www.thewellbio.com or contact customer service at 1.866.3D.CELLS.

About TheWell Bioscience Inc.

TheWell Bioscience delivers the industry’s most comprehensive, end-to-end, xeno-free workflow for robust and reproducible 3D cell models. Through an integrated ecosystem of xeno-free biofunctional hydrogels, cell culture media, and 3D cell culture vessels, the company eliminates the variability associated with animal-derived materials and enables scalable solutions for precision medicine, cell therapy, and biomanufacturing. The platform also supports the advancement of New Approach Methodologies (NAMs) by enabling more human-relevant, reproducible in vitro models for research and drug development.

TheWell Bioscience Inc.:
Tel: +1 973-855-4955
E-mail: media@thewellbio.com

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