Using VitroGel® to model tumor–stroma crosstalk in 3D and uncover new therapeutic targets in skin cancer. Solar UV-induced skin cancers, like cutaneous squamous cell carcinoma (cSCC), are driven not only by cancer cells themselves but also by their interaction with surrounding fibroblasts. Traditional 2D cultures fail to replicate this complex tumor–stroma communication, limiting our understanding […]
VitroGel® and its Cell Recovery Solution streamline 3D culture and cell isolation for high-impact tumor microenvironment studies. Understanding the mechanisms driving nasopharyngeal carcinoma (NPC) progression and metastasis requires physiologically relevant in vitro models. In this study, researchers investigated how FLT1-enriched extracellular vesicles (EVs) mediate a pro-metastatic feedback loop between NPC cells and endothelial cells. To […]
VitroGel® ORGANOID-3 enabled the successful creation of patient-derived 3D meningioma models that closely mimicked primary tumor structure, biomarker expression, and epigenetic profiles in a xeno-free, reproducible system. Meningioma treatment faces significant hurdles, particularly due to the lack of effective preclinical models that mimic the complex biology of individual tumors. Traditional two-dimensional (2D) cell cultures oversimplify […]
VitroGel® takes the fight to fibrosis—making cell invasion studies faster, clearer, and more reliable. Pulmonary fibrosis, especially when triggered by toxins such as paraquat, is a life-threatening condition driven by inflammation, epithelial-mesenchymal transition (EMT), and invasive cell behavior. To understand and halt this progression, researchers require a physiologically relevant in vitro system that can mimic […]
This study leveraged VitroGel®’s hydrogel system to model the tumor microenvironment and uncover the role of TIMP1 in driving venous invasion in pancreatic cancer. Hydrogel: VitroGel® Hydrogel Matrix (VHM01) Pancreatic ductal adenocarcinoma (PDAC) is characterized by its aggressive nature and poor prognosis, often driven by early vascular invasion and metastasis. In this study, researchers focused […]
VitroGel® IKVAV was a key component that enabled stable vessel formation, proper cellular organization and functional BBB behavior in the 3D microfluidic model. Hydrogel: VitroGel® IKVAV (Cat. No: TWG007) The blood-brain barrier (BBB) presents a major challenge in neuro-oncology and CNS drug development due to its highly selective nature, which restricts the passage of most […]
VitroGel® Hydrogel Matrix enables the controlled delivery of bioactive Qu-SeNPs, accelerating bone defect healing and enhancing therapeutic potential for regenerative medicine. Hydrogel: VitroGel® Hydrogel Matrix (Cat. No: VHM01) The development of biomimetic hydrogels has significantly advanced the field of regenerative medicine by providing an extracellular matrix-like environment that supports cell survival and function. In bone […]
VitroGel® supports 3D spheroid models for evaluating basroparib’s efficacy in overcoming MEK inhibitor resistance in KRAS-mutated colorectal cancer. Hydrogel:VitroGel® RGD (Cat. No: TWG003) The study on basroparib’s role in overcoming MEK inhibitor resistance in KRAS-mutated colorectal cancer (CRC) highlights the importance of innovative in vitro models that accurately recapitulate tumor microenvironments. Using VitroGel®, a versatile, […]
VitroINK® provided a xeno-free, structurally supportive bioink that enabled the precise 3D bioprinting of a functional testis model, facilitating cell viability, maturation, and in vitro spermatogenesis research. Fertility preservation following pediatric cancer therapy has become a critical area of research, as over 80% of childhood cancer survivors reach adulthood, yet up to 66% of male […]
VitroGel® 3D provided a scaffold-free yet supportive matrix that stabilized adipose organoids for imaging and analysis, enhancing the reliability of in vitro obesity research. Obesity and metabolic diseases remain urgent global health challenges, yet studying human adipose tissue in vitro is complicated by the limitations of 2D cultures and scaffold-based models. Traditional methods often fail […]
