Author Archives: Kyra Baricaua

Revolutionizing Cancer Research: A Patient-Derived Platform to Model Tumor-Immune Interactions

BiomarkerCyto3D® Live-Dead Assay Kit (Cat. No: BM01) Cancer research has long been challenged by the complexity of tumor-immune interactions. Traditional 2D cell cultures and animal models often fail to capture the intricate tumor microenvironment (TME), limiting their relevance to human biology. Patient-derived precision-cut tumor slices (PCTS) offer a promising solution by preserving the tumor’s architecture […]

Game Changer for Lymphoma Therapy Screening

VitroGel® RGD played a key role in preserving tumor architecture for effective drug testing in lymphoma research. Hydrogel: VitroGel® RGD (Cat. No: TWG003) VitroGel® played a The fight against cancer, particularly B-cell lymphomas, is challenged by the complexity of tumor microenvironments and the need for personalized treatment strategies. Traditional models such as cell lines and […]

Prolonged Dexamethasone Delivery Using VitroGel® for Protection Against Cisplatin-Induced Ototoxicity

VitroGel® significantly enhanced the delivery of dexamethasone to the inner ear, providing controlled release and improved protection against cisplatin-induced hearing loss. Hydrogel: VitroGel® RGD (Cat. No: TWG003) VitroGel® played a crucial role in the study by enhancing the local delivery of dexamethasone (Dexa) to the inner ear. It facilitated a controlled and prolonged release of […]

Harnessing Patient-Derived Organoids to Decode Immunotherapy Responses in Colorectal Cancer

VitroGel® revolutionizes colorectal cancer research by creating a xeno-free platform for patient-derived organoids, enabling groundbreaking insights into tumor-immune interactions and immunotherapy responses. Hydrogel: VitroGel® MSC (Cat. No: VHM03) Other VitroGel® option: VitroGel® ORGANOID-3 (Cat. No: VHM04-3) VitroGel® played a crucial role in establishing a patient-derived immunity-organoid interaction platform for colorectal cancer (CRC) research. By providing […]

VitroGel® ORGANOID Unlocks Precision High-Throughput Drug Screening Insights in Ovarian Cancer

VitroGel® ORGANOID empowered breakthrough single-cell pharmacotranscriptomic profiling by enabling robust, patient-specific cancer organoid models for drug discovery and resistance analysis. Hydrogel: VitroGel® ORGANOID-4 (Cat. No: VHM04-4) In this study, Dini et al. present a high-throughput pharmacotranscriptomic pipeline utilizing live-cell barcoding and single-cell RNA sequencing (scRNA-Seq) to analyze drug response mechanisms and resistance pathways in high-grade […]

VitroGel® ORGANOID Reveals Unique Pathway Shifts in HOSE Cells Exposed to Tumor Microenvironment

VitroGel® ORGANOID-4 deepened ovarian cancer research by allowing 3D spheroid formation and transcriptomic analysis, identifying key signaling STAT1 and GREM1 activation pathways. Institutions:University of Oulu; Institute for Molecular Medicine Finland; University of Helsinki; Tampere University Hospital and Faculty of Medicine and Health Technology; Okayama University Graduate School of Medicine; Karolinska Institutet. Team:Emilia Piki, Alice Dini, […]

2024 in Review: TheWell Bioscience Milestones, Growth, and Vision for 2025

2024 in Review: TheWell Bioscience Milestones, Growth, and Vision for 2025 We’re excited to celebrate the milestones that defined this remarkable year. We extend our heartfelt gratitude to all the researchers, collaborators, and partners who have supported us in advancing VitroGel® for 3D cell culture, driving innovation in biomedicine and beyond.

TheWell Bioscience 2024 Innovations for Advancing 3D Cell Culture

2024 Innovations for Advancing 3D Cell Culture This year has marked remarkable growth and innovation for TheWell Bioscience. We introduced groundbreaking products, including the VitroGel® Invasion Assay Kits, VitroGel® Starter Kits, VitroPrime Cell Culture Inserts, and VitroPrime Spread-Attach Plate. These innovations further enhance our comprehensive workflow for full lab automation, empowering researchers to achieve greater […]