Author Archives: Kyra Baricaua

Understanding Cell Culture Definitions

As cell culture workflows become more defined and application-specific, understanding the terminology used to describe matrix, medias and supplements is increasingly important. Why Do These Definitions Matter? Choosing the right formulation can help researchers establish a more controlled and reproducible culture environment. For applications such as stem cell culture, differentiation, 3D culture, organoid development, and […]

Ready, Set, Culture: Advancing Cell Culture Research with Solutions from TheWell Bioscience

The lab is back in session! As you kick off a new season of research, let us help you build a more defined, reproducible, and scalable cell culture workflow. Discover the latest solutions from TheWell Bioscience, designed to take your research from everyday cell culture to advanced 3D models while supporting the advancement of New […]

Culture Apical-Out Organoids with Synthetic VitroGel® System

Another limitation of animal-based ECMs is that organoids typically develop an apical-in polarity, where the apical surface is enclosed within the organoid. This makes studies of nutrient absorption, drug transport, and host-microbiome interactions difficult, often requiring labor-intensive methods such as microinjection or suspension culture to access the apical surface. VitroGel® ORGANOID is a synthetic, chemically […]

Generation of Apical-out Intestinal Organoids Using Xeno-free VitroGel® ORGANOID

Poster on apical-out intestinal organoids using VitroGel ORGANOID; includes timeline, methods, and multiple microscopy panels.

Background: Organoids are 3D self-organizing tissue models that closely mimic the architecture and function of native organs.​ Epithelial polarity is a fundamental feature of intestinal organoids, governing nutrient absorption, drug transport, and barrier function.​ Conventional Matrigel-grown intestinal organoids exhibit an apical-in orientation, restricting direct access to the absorptive epithelial surface.​ Apical-out intestinal organoids expose the […]

TheWell Bioscience Launches RocketCell™ Cell Viability Enhancer to Maximize Cell Recovery, Survival, and Growth for Stem Cell and Organoid Research

Press release banner announcing TheWell Bioscience's RocketCell cell viability enhancer for stem cell research, with a vial on the right.

Proprietary small-molecule cocktail significantly improves post-passaging recovery, cryopreservation outcomes, and long-term expansion of sensitive cell cultures. MONMOUTH JUNCTION, N.J., July7, 2026 — TheWell Bioscience, a leader in xeno-free 3D cell culture technologies, today announced the commercial launch of RocketCell™ Cell Viability Enhancer, a proprietary small-molecule formulation designed to maximize cell survival, metabolic recovery, and growth […]

3D Hydrogel Embedding Boosts the Immunomodulatory Power of human gingiva-derived Stem Cells: A New Strategy for Regenerative Medicine

Fluorescent images of green-labeled cells under four cytokine treatments on three substrates (3D hydrogel, hydrogel, and 2D TCP).

VitroGel® MSC hydrogel enhances anti-inflammatory response in human gingiva-derived mesenchymal stromal cells (hG-MSCs), offering a promising approach to optimize cell-based therapies for inflammatory diseases. Mesenchymal stromal cells (MSCs) have emerged as promising candidates for regenerative medicine due to their remarkable ability to modulate the immune system and promote tissue repair. These cells can be isolated […]