FGF-19 (Human), Recombinant Protein, E. coli, Tag Free
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CytoGrow™ Recombinant FGF-19 (Human), E.coli, Tag Free
Recombinant human fibroblast growth factor 19 (FGF-19) is produced in E. coli in a tag-free format, ensuring high purity and reliable biological activity. FGF-19 is a member of the endocrine FGF subfamily and functions as a key regulator of metabolic processes, including bile acid synthesis, glucose metabolism, and energy homeostasis.
In humans, FGF-19 binds to fibroblast growth factor receptors (primarily FGFR4) in the presence of the co-receptor β-Klotho, activating downstream signaling pathways such as MAPK/ERK and STAT. These pathways regulate bile acid production in the liver, as well as lipid and glucose metabolism. FGF-19 also plays a role in cell proliferation and liver regeneration. Recombinant FGF-19 is widely used in metabolic research, liver biology studies, and investigations of endocrine FGF signaling pathways.
| Synonym: | |
| Species: | Human |
| Expression System: | E. coli |
| Endotoxin: | ≤100 EU/mg |
| Appearance: | White powder, colorless clear liquid after reconstitution |
| Formulation | Lyophilized from a 0.22 μm filtered solution containing 20 mM Sodium Acetate, 5% Trehalose, and 0.01% Tween 80 |
| Reconstitution: | Recommended to redissolve in sterile deionized water |
| Shipping: | US - Ships overnight |
| Storage and Stability: | Store in a manual defrost freezer and avoid repeated freeze-thaw cycles. Lyophilized state: 36 months at -20°C to -80°C After reconstitution and under sterile conditions: 6 months at -20°C to -80°C 7-10 days at 2°C to 8°C |
Measured in a cell proliferation assay using murine NIH3T3 cells. The ED50 for this effect is ≤5μg/ml.
Data and Bioactivity
| Size | 1 μg, 10 µg, 50 μg, 1 mg, 10 mg, 100 mg, 1 g, 1 mL, 10 mL |
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