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Bridging 2D and 3D Stem Cell Culture
New Resource:
The Comprehensive Guide to Xeno-Free Stem Cell Research
As stem cell research continues to move toward defined, animal component-free workflows, selecting the right culture platform has become increasingly important for achieving reproducible, clinically relevant results. Advances in xeno-free technologies are helping researchers improve consistency, simplify regulatory pathways, and build more physiologically relevant in vitro models.
To support scientists navigating this transition, TheWell Bioscience has released the Xeno-Free Stem Cell Research Product Guide—a practical resource that brings together optimized workflows, recommended products, and application-specific solutions across the stem cell culture pipeline.
Inside the guide, you’ll discover:
- Xeno-free workflows from pluripotent stem cell maintenance to advanced 3D culture
- Solutions for iPSC, hMSC, NSC, and organoid applications
- Synthetic hydrogel systems designed to replace animal-derived ECMs
- Defined media, growth factors, cultureware, and downstream analysis tools
- End-to-end strategies for building reproducible 2D and 3D stem cell culture workflows
Whether you’re establishing a new xeno-free workflow or optimizing an existing protocol, this guide provides a concise reference to help streamline experimental design and support reproducible research.
Download the free Xeno-Free Stem Cell Research Product Guide today and discover an integrated approach to bridging the gap from conventional 2D culture to advanced 3D stem cell models.
Explore our End-to-End Platform for Stem Cell Culture
Discover how these solutions work together to simplify and streamline stem cell research.
VitroGel® Xeno-Free Hydrogel
VitroGel® STEM is a xeno-free, animal origin-free hydrogel system designed to support the expansion, scale-up, and 3D differentiation of human pluripotent stem cells (hPSCs). It enables high-throughput tissue and disease modeling and is optimized for static suspension culture and scalable stem cell production.
RocketCell™ 3D iPSC Xeno-Free Complete Growth Kit
An all-in-one xeno-free kit with optimized matrix, medium, and reagents for 3D iPSC expansion. Optimized to support the 3D expansion of pluripotent stem cells (iPSCs and hESCs) and both single-cell and small-colony seeding while maintaining excellent post-passaging viability. This kit enables alternate-day feedings and a weekend-free schedule, providing flexibility for diverse research schedules.
RocketCell™ Organoid Xeno-Free Essential-Core Medium
A universal, chemically defined foundation medium that supports multiple organoid types with a single formulation—reducing reagent costs and waste by minimizing the need for multiple specialized media purchases.
CytoGrow™ Growth Factors
Premium-grade recombinant proteins, delivering high bioactivity, strong lot-to-lot consistency, and reliable performance at a budget-friendly price. With 100+ proteins across multiple species, it covers all major growth factor families and essential cell culture components.
VitroPrime™ 3D Culture and Imaging Plate
Designed to solve common challenges in 3D hydrogel culture. A built-in retention compartment keeps gels in place, preventing floating or movement for stable imaging and accurate tracking. All steps—from culture to staining and imaging—can be done in one plate, reducing sample loss, protecting delicate structures, and simplifying workflows.
VitroGel® Organoid Recovery Solution
VitroGel® Organoid Recovery Solution is a non-enzymatic cell/organoid harvesting solution for quick and efficient recovery of 3D cells or organoids cultured with either VitroGel® hydrogels or an animal-based ECM.
Cyto3D® Live-Dead Assay Kit
The Cyto3D® Live-Dead Assay Kit is a quick one-step staining procedure for analysis on a dual-fluorescence system and versatile live/dead assay for 3D and 2D Cell Culture, Organoids, Spheroids, Stem Cells, and Fluorescence Microscopy.
