CytoGrow™ Recombinant Insulin (Bovine), Yeast, Tag Free

Recombinant bovine insulin is produced in yeast in a tag-free format, ensuring correct disulfide bond formation and high biological potency. Insulin is a small, two-chain polypeptide hormone that serves as a primary regulator of glucose homeostasis, lipid metabolism, and protein synthesis across various mammalian species.

In cell culture applications, bovine insulin functions as a critical growth factor by binding to the insulin receptor (IR) and the insulin-like growth factor-1 receptor (IGF-1R), activating key signaling pathways such as PI3K/Akt and MAPK. This recombinant version offers a strictly animal-origin free (AOF) solution, mitigating the risks of viral or prion contamination associated with traditional pancreas-derived sources. Its tag-free nature and high purity make it an essential component for maintaining cell viability and promoting proliferation in complex, chemically defined environments.

Measured in a cell proliferation assay using MCF-7 human breast cancer cells.